2015-07-01
Vulcanchem offers qualified products for CAS No. 552309-42-9(T16Ainh-A01), please inquire us for more detail.
View and buy high purity T16Ainh - A01. Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. Cited in 8 publications. T16Ainh-A01 relax rodent resistance arteries in a concentration dependent way, an equivalent vasorelaxation occurs in rodent arteries when the transmembrane chloride gradient is abolished with an impermeant anion), 23 this reduces the reliability of T16Ainh-A01's dependence on TMEM16A. T16AInh-A01 | C19H20N4O3S2 | CID 135460621 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). - Mechanism of Action & Protocol.
552309-42-9. C19H20N4O3S2. Welcome About BGC Terms of Use MSDS Banner Adverts EINECS. Formel. T16Ainh - A01. 552309-42-9.
The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications. In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+. References:
References: [1] Alison J Davis, et al. Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh-A01. Br … Vulcanchem offers qualified products for CAS No. 552309-42-9(T16Ainh-A01), please inquire us for more detail.
Download scientific diagram | Chemical structures of benzophenanthridine alkaloids and T16Ainh-A01. Chemical structures of sanguinarine, sanguinarine
T16Ainh - A01 Ca 2+ -activated Cl - channel transmembrane protein 16A (TMEM16A) inhibitor CAS# 552309-42-9 Catalog No. BCC6220 ----Order now to get a substantial discount! The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications. In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+. References: The voltage-dependent component disappears due to VGCC inhibition, suggesting that Ca2+ is the essential trigger for ANO1. In perforated current-clamping method, the application of T16Ainh-A01 and reduction of Cl− extended excitation periods in rod bipolar cells, revealing that ANO1 induces repolarization during excitation.
Buy Calcium Channel inhibitor T16Ainh - A01 from AbMole BioScience.
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T16AInh-A01. T16Ainh - A01. t16a(inh)-a01. 2-((5-Ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 is a potent and selective inhibitor of calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) with IC50 of 1.8 μM.
These data indicate that TRPC6 channels generate a local intracellular Ca(2+) signal that activates nearby ANO1 channels in myocytes to stimulate vasoconstriction.
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View and buy high purity T16Ainh - A01 from Tocris Bioscience. Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. Cited in 8 publications.
References: The voltage-dependent component disappears due to VGCC inhibition, suggesting that Ca2+ is the essential trigger for ANO1. In perforated current-clamping method, the application of T16Ainh-A01 and reduction of Cl− extended excitation periods in rod bipolar cells, revealing that ANO1 induces repolarization during excitation.
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The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications. In rabbit pulmonary artery myocytes T16Ainh-A01 (1–30 μM) inhibited single calcium (Ca2+)-activated whole cell currents activated by 500 nM free Ca2+. References:
T16AInh-A01 | C19H20N4O3S2 | CID 135460621 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Welcome to PubChem! … T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh-A01 is a potent and selective inhibitor of calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) with IC50 of Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations. View and buy high purity T16Ainh - A01 from Tocris Bioscience.